Lipoprotein oxidation and lipoprotein-induced cytotoxicity.
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چکیده
منابع مشابه
Lipoprotein oxidation and lipoprotein-induced cytotoxicity.
The results of this study indicate that when human VLDL or LDL is prepared under conditions allowing oxidation, such oxidation renders the molecular complexes highly toxic to human skin fibroblasts growing in culture. The cytotoxicity can be predicted by assaying for the presence of thiobarbituric acid-reacting substances on the lipoprotein. However, malondialdehyde, which reacts with thiobarbi...
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Increased lipid peroxidation products were detected in a lipoprotein fraction containing very low density lipoprotein (VLDL) and low density lipoprotein (LDL) obtained from rats made diabetic by streptozotocin injection. The enhanced oxidation in the diabetic VLDL plus LDL fraction correlated with the in vitro toxicity of this lipoprotein fraction to proliferating fibroblasts. In contrast, high...
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Lipoprotein oxidation is a key early stage in the development of atherosclerosis. Oxidation of low-density lipoprotein (LDL) is initiated by both enzyme-mediated and non-enzymic mechanisms in vivo, and oxidized LDL has many atherogenic properties. Oxidation of LDL in vivo is likely to be influenced by local environmental factors, such as pH. The composition of LDL is also important, including s...
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Background. Data continue to accumulate supporting a proatherogenic role for oxidized low-density lipoprotein (Ox-LDL). Antioxidant micronutrients such as ascorbate, a-tocopherol, and beta carotene, levels of which can be favorably manipulated by dietary measures without side effects, could be a safe approach in inhibiting LDL oxidation. In fact, in vitro studies have shown that all three antio...
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ژورنال
عنوان ژورنال: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
سال: 1983
ISSN: 0276-5047
DOI: 10.1161/01.atv.3.3.215